These actions align with the types of tissue repair in bone, cartilage, and muscle that are essential in managing OA [1]
## Storage After Reconstitution - **Refrigerate** at 36-46 degrees F (2-8 degrees C) immediately after reconstitution - **Use within 28-30 days** - **Protect from light** -- store in the original box or wrap in foil - **Never freeze** reconstituted solution - **Check before each use** -- if cloudy, discolored, or containing particles, discard ### Before Reconstitution (Unreconstituted Powder) - Refrigerate or store at controlled room temperature per the label - Check expiration date - Keep dry and protected from moisture ## Injection Technique ### Preparing Your Dose 1
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Long-term metformin use (the first-line type 2 diabetes drug) can lower B12 in a dose- and duration-dependent way: in the Diabetes Prevention Program Outcomes Study (Aroda and colleagues, The Journal of Clinical Endocrinology & Metabolism , 2016, roughly 1,700 participants), low B12 at 5 years occurred in 4.3 percent of metformin users versus 2.3 percent on placebo, and the gap widened with continued use
